Entry ( &2 ) is already in the database table ( &1 )

What causes this issue?

Entry could not be inserted into database table. Entry with the same
primary key was already in the database.
The primary key of the duplicate entry is:
&V2&
&V3&
&V4&

System Response

Exception CX_SY_OPEN_SQL_DB was raised due to duplicates inserted into
DB.
Rollback Work was done, and no data were inserted into database.

How to fix this error?

If the affected table is a RAI table, you should check that your sender
component system does not create RAIs with identical timestamps. Be
aware, that the data quality "exactly once" is required.
For other tables contact your system administrator or SAP support.

Procedure for System Administrators

The system issues an error message and will not allow you to continue with this transaction until the error is resolved.

Error message extract from SAP system. Copyright SAP SE.